We report the results of the WMT 2022 shared task on Quality Estimation, in which the challenge is to predict the quality of the output of neural machine translation systems at the word and sentence levels, without access to reference translations. This edition introduces a few novel aspects and extensions that aim to enable more fine-grained, and explainable quality estimation approaches. We introduce an updated quality annotation scheme using Multidimensional Quality Metrics to obtain sentence- and word-level quality scores for three language pairs. We also extend the Direct Assessments and post-edit data (MLQE-PE) to new language pairs: we present a novel and large dataset on English-Marathi, as well as a zero-shot test-set on English-Yoruba. Further, we include an explainability sub-task for all language pairs and present a new format of a critical error detection task for two new language pairs. Participants from 11 different teams submitted altogether 991 systems to different task variants and language pair.